Sidorenko Svetlana P.

EDUCATIONAL HISTORY
B.Sc. 1975 Kiev State University, Kiev, U.S.S.R. Cytology/Histology
Ph.D. 1980 Institute for Oncology Problems Acad.Sci. Ukraine, Kyiv, U.S.S.R Experimental Oncology

D.Sc. 1999 Kavetsky Institute of Experimental Pathology, Oncologyand Radiobiology National Academy of Sciences, Kiev, Ukraine, Oncology

POSTDOCTORAL RESEARCH TRAINING
1981 Prof. Julian A. Umansky, M.D., Ph.D.; Institute for Oncology Problems Acad. Sci. Ukraine, Department of Tumor Immunology, Kiev, U.S.S.R.; tumor immunology.
1982 Prof. Gary I. Abelev, Ph.D.; All-Union Cancer Research Center, Department of Immunochemistry; Moscow, U.S.S.R.; tumor immunology

RESEARCH AND ACADEMIC POSITIONS
1983-1984 Junior Scientist, Institute for Oncology Problems Acad. Sci. Ukraine, Department of Cytochemistry and Immunocytology, Kiev, U.S.S.R.
1985 Senior Scientist, Institute for Oncology Problems Acad. Sci. Ukraine, Department of Cytochemistry and Immunocytology, Kiev, U.S.S.R.
1986 Visiting Scientist, All-Union Cardiology Research Center, Depatrment of Immunology (with Professor Oscar V. Rokhlin), Moscow, U.S.S.R.
1987- 1996 Senior Scientist, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology Ukrainian Academy of Sciences, Kiev, U.S.S.R, Ukraine.
08.1989 Guest Scientist, Radiology and Oncology Institute, Department of Immunology, Havana, Republic of Cuba.
09.1991-05.1992 Foreign Senior Fellow; International Union Against Cancer: American Cancer Society Eleonor Roosevelt International Cancer Research Fellowship; University of Washington Department of Microbiology (c/o Prof. E.A.Clark), Seattle, USA.
06.1992- 06.1994 Visiting Scientist, University of Washington, Department of Microbiology, Seattle, USA.
07.1994 - 06.1996 Research Associate, Department of Microbiology, University of Washington, Seattle, WA, USA
02.1997 - 09.2004 Visiting Scientist, Department of Microbiology, University of Washington, Seattle, WA, USA
08.1995 - 08.2001 Howard Hughes Medical Institute International Research Scholar
07.1996 - 02.2000 Senior Scientist, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
02.2000 - 04.2003 Leading scientist at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
01.2001 - present Expert of INTAS
05.2003 - present Head, Laboratory of Signal Transduction Pathways, Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kiev, Ukraine

HONORS AND AWARDS

1989 Special prize and silver medal for "Monoclonal antibodies against B cell differentiation antigens" at the exhibition "Genetic and cell engineering-scientific foundation for biotechnology", Moscow.
1991 International Union Against Cancer: American Cancer Society International Cancer Research Fellowship.
1993-present Member of the Association of UICC Fellows, International Union Against Cancer, Geneva, Switzerland.
1995-2001 International Research Scholar's award from the Howard Hughes Medical Institute (grant 75195-548101)
1996 Travel Grant from 6th International Workshop on Human Leucocyte Differentiation Antigens
1997-1999 CRDF grant UN2-437.
1997-present Member of the American Association of Immunologists
1997-1999 INTAS grant 96-1493
1998 Degree Doctor in biological Sciences, Dr.Sci., Kiev, Ukraine
2003 FEBS Travel grant.
2001-2003 CRDF grant UN2-531.
2004-present Vice-president of Ukrainian Cell Biology Society.
2004-2006 CRDF grant UB2-2443-KV-02.
2005-present National Institutes of Health FOGARTY INTERNATIONAL CENTER
Grant Number: 1 R03 TW007322-01

SELECTED PUBLICATIONS
(From over 160 publications)

Original reports
1. Pinchouk, V.G., S.P. Sidorenko, D.F. Gluzman, E.P. Vetrova, A.G. Berdova, L.N. Shlapatskaya. Monoclonal antibodies IPO-3 and IPO-10 against human B cell differentiation antigens. Anticancer Research 8:1377-1380, 1988.
2. Sidorenko, S.P., D.F. Gluzman, E.P. Vetrova, O.V. Iurchenko, A.G. Berdova. Morphocytochemical and electron microscopic research on murine hybridoma cells producing and not producing monoclonal antibodies. Cytology 30:39-43. 1988. (Russian).
3. Sidorenko, S.P., A.G. Berdova, E.P. Vetrova, D.F. Gluzman. Monoclonal antibodies IPO-4 recognizing the antigen of activated T and B human lymphocytes. Exper. Oncology 12: 21-24, 1990.(Russian)
4. Sidorenko, S.P., E.P. Vetrova, O.V. Yurchenko, A.G. Berdova, D.F. Gluzman. Monoclonal antibodies of IPO series in study and diagnosis of malignant lymphoprolipherative diseases. Haematology and Transfusiology 35: 19-22, 1990.(Russian)
5. Gluzman, D.F., S.P. Sidorenko, L.Iu. Poludnenko, O.V. Iurchenko, B.Y Goldshmid. Current theories on the origin of Reed-Sternberg cells in lymphogranulomatosis . Haematology and Transfusiology 35:24-27, 1990. (Russian)
6. Gluzman, D.F., V.A. Nadgornaya, L.M. Skliarenko, I.V. Abramenko, S.P. Sidorenko, E.V. Kazmina, E.A. Livshits, V.D. Drozdova. Immunoenzyme cytochemical methods, monoclonal antibodies and lectins in the diagnosis of tumors of the lymphoid tissue in children. Pediatriia.11:18-22, 1991.(Russian)
7. Sidorenko, S.P., E.P. Vetrova, O.V. Yurchenko, A.G. Berdova, L.N. Shlapatskaya, D.F. Gluzman. Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping. Neoplasma 39: 3-9, 1992.
8. Sidorenko, S.P., and E.A. Clark. Characterization of a cell surface glycoprotein IPO-3, expressed on activated human T and B lymphocytes. J. Immunol. 151:4614-4624, 1993.
9. Law, C.-L., S.P. Sidorenko, K.A. Chandran, K.E. Draves, A.C. Chan, A. Weiss, S. Edelhoff, C.M. Disteche, and E.A. Clark. Molecular cloning of human Syk, a B cell protein tyrosine kinase associated with the sIgM/B cell receptor complex. J. Biol. Chem. 269: 12310-12319, 1994.
10. Sidorenko, S.P., L.N. Shlapatskaya, E.P. Vetrova, A.G. Berdova, O.V. Yurchenko, T.T. Klenova, S.V. Michalap, I.V. Abramenko, and D.F. Gluzman. Monoclonal antibodies IPO-38 against nuclear antigen of proliferative cells. Exp. Oncol. 16:145-150, 1994.
11. Sidorenko, S.P., C.-L. Law, K.A. Chandran, and E.A. Clark. Human spleen tyrosine kinase, p72Syk, associates with the Src-family kinase p53/56Lyn and a 120 kDa phosphoprotein. Proc. Natl. Acad. Sci. 92:359-363, 1995.
12. Law, C.-L., S.P. Sidorenko, K.A. Chandran, Z. Zhao, E.H. Fisher, and E.A. Clark. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C- 1 upon B cell activation. J. Exp. Med. 183:547-560, 1996.
13. Law, C.-L., K.A. Chandran, S.P. Sidorenko, and E.A. Clark. Phospholipase C 1interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16:1305-1315, 1996.
14. Klaus S. J., S.P. Sidorenko, and E.A. Clark. CD45 ligation induces programmed cell death in T and B lymphocytes. J. Immunol. 156:2743-2753, 1996.
15. Polacino, P.S., L.M. Pinchuk, S.P. Sidorenko, and E.A. Clark. Immunodeficiency virus cDNA synthesis is regulated by T cell activation signals and dendritic cells. J. Med. Primatol. 25:201-209, 1996.
16. Sidorenko, S.P., C.-L. Law, S.J. Klaus, K.A. Chandran, M. Takata, T. Kurosaki, and E.A. Clark. Protein kinase C mu (PKC ) associates with the B cell receptor and regulates lymphocyte signaling. Immunity 5:353-363, 1996.
17. Rokhlin, O.W. , G.A. Bishop, B.S. Hostager, T.J. Waldschmodt, S.P. Sidorenko, N. Pavloff, M.C. Kiefer, S.R. Umansky, R.A. Glover, and M.B. Cohen. Fas-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res. 57:1758-1768, 1997.
18. Rokhlin, O.W., B.S. Hostager, G.A. Bishop, S.P. Sidorenko, R.A. Glover, A.V. Gudkov, and M.B. Cohen. Dominant nature of the resistance to Fas- and tumor necrosis factor-alpha-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res. 57:3941-3953, 1997.
20. Sidorenko, S.P. CDw150. Protein Reviews On The Web. - http://www.ncbi.nlm.nih.gov/prow/cd/cdw150.htm - 1997. - P. 4.
21. Sidorenko, S.P. CD95/Fas-mediated apoptosis in the pathogenesis of lymphoid neoplasms. Exp. Oncol. 20:15-28, 1998.
22. Chekhun, V.F., Yu.Shishova., O.V.Yurchenko, L.N. Shlapatskaya, S.V.Mikhalap, A.G.Berdova, Sidorenko, S.P., G.I.Kulik., D.F.Gluzman. Synergistic cytotoxic effect of cisplatin and monoclonal anti-FAS IPO-4 antibodies on human epidermoid carcinoma cell line KB. Exp. Oncol. 20:210-217, 1998.
23. Mikhalap, S.V., L.N. Shlapatskaya, A.G. Berdova, C.-L. Law, E.A. Clark. and S.P. Sidorenko. CDw150 associates with Src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. J.Immunol. 162: 5719-5727, 1999.
24. Chekhun, V.F., Yu.Shishova., O.V.Yurchenko, M.A. Vodyanik, S.P.,Sidorenko. Drug resistance in KB/DDP5 cells associated with hypersensitivity to CD95-mediated apoptosis. Exp. Oncol. 22(Suppl.2): 20-26, 2000.
25. Sidorenko, S.P., O.V.Yurchenko, L.N. Shlapatskaya, S.V.Mikhalap, A.G.Berdova, T.J.Yun, K.E.Nichols, E.A.Clark. CDw150 is a signaling molecule that modulates CD95-mediated apoptosis. Exp. Oncol. 22(Suppl.2): 27-35, 2000.
26. Mikhalap, S.V., L.N. Shlapatskaya, A.G. Berdova, O.V.Yurchenko, Lopes F., Lukyanova N.Y., and S.P. Sidorenko. Monoclonal antibody IPO-38 in evaluation of proliferative activity of tumor cells. Exp. Oncol. 22(Suppl.2): 36-38, 2000.
27. Shlapatska, L.M., S.V. Mikhalap, A.G. Berdova, O.M Zelensky., T.J.Yun, K.E. Nichols, E.A. Clark. and S.P. Sidorenko. CD150 association with either the SH2-containing inositol phosphatase (SHIP) or SHP-2 is regulated by the adaptor protein SH2D1A. J.Immunol, 166:5480-5487, 2001.
28. Hobta A, Lisovskiy I, Mikhalap S, Kolybo D, Romanyuk S, Soldatkina M, Markeyeva N, Garmanchouk L, Sidorenko SP, Pogrebnoy PV. Epidermoid carcinoma-derived antimicrobial peptide (ECAP) inhibits phosphorylation by protein kinases in vitro. Cell Biochem Funct.19(4):291-298, 2001.
29. Mikhalap, S.V., L.N. Shlapatskaya, A.G. Berdova, M.Y.Yurchenko, Clark E.A., Chekhun, V.F and S.P. Sidorenko. ERK and Akt activation via CD150: signal transduction studies on DT40 cell line model system. Exp. Oncol. 24:13-19, 2002.
30. O.V.Yurchenko, L.M. Shlapatska, M.V. Skryma, G.G.Berdova, L.M.Kovalevska, T.A. Tarasova, M.Y.Yurchenko, G.I. Kulik, and S.P.Sidorenko. Immunohistochemical studies of CD150 expression in some human tumors. Exp. Oncol. 25: 186-190, 2003.
31. Shlapatska, L.M., G.G. Berdova, L.M.Kovalevska, G.I.Kulik S.P. Sidorenko, G. Klein, and Chekhun, V.F Signal transduction pathways in Burkitt's lymphoma cell lines BL41 and DG75 with different sensitivity to doxorubicine. Exp. Oncol. 26:210-216, 2004.
32. Mikhalap SV, Shlapatska LM, Yurchenko OV, Yurchenko MY, Berdova GG, Nichols KE, Clark EA, Sidorenko SP. The adaptor protein SH2D1A regulates signaling through CD150(SLAM) in B cells. Blood, 104 (13): 4063-70, 2004.
33. Yurchenko MY, Kashuba EV, Shlapatska LM, Sivkovich SA, Sidorenko SP. The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma cell lines.
Exp Oncol. 27(1):24-30, 2005.
34. Kovalevska LM, Yurchenko OV, Shlapatska LM, Berdova GG, Mikhalap SV, Van Lint J, Sidorenko SP. Immunohistochemical studies of protein kinase D (PKD) 2 expression in malignant human lymphomas. Exp Oncol. 28(3):225-30, 2006.
35. Mikhalap S. V. Kovalevska L. M. Sidorenko S. P. The role of PKD family protein kinases es in the regulation of protein post-translational modification (Reviews) Ukrainian biochemical jornal 2008, T 80, № 4.16-24.
36. Ржапецький Ю.А., Самойленко А.А., Кухаренко О.П., Міхалап С.В., Сидоренко С.П., Гауссер А., Дробот Л.Б. Протеїн кіназа D взаємодіе з адаптерним білком RUK/CIN85 і фосфорилює його. Біологічні студії. 2009,3 №3. 17-28 с.
37. Rzepetsky Yu.A., Samoylenko A.A., Kukharenko O.P., Mikhalap S.V., Sidorenko S.P., Hausser A., Drobot L.B. Protein kinase D in interacts with adaptor protein RUK/CIN85 and phosphorylates it. Studia Biologica. 2009,3 №3. 17-28 с.
37. Shabelnik M.Y., Kostyuk O.V., Merentsev S.V., Sidorenko SP. Helicobacter pylori infection of gastric cancer cells elevates the level of expression and activation of protein kinase D2. Exp Oncol. 2009 (3): 134-9.
38. Yurchenko MY, Kovalevska LM, Shlapatska LM, Berdova GG, Clark EA, Sidorenko SP. CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 2010 Mar 16

Reviews and Book Chapters

1. S.P.Sidorenko, E.P.Vetrova, L.N. Shlapatskaya, A.G. Berdova. Monoclonal antibodies against cell lineage-specific and differentiation antigens of hemopoietic and lymphoid tissues. In: Immunocytochemistry and monoclonal antibodies in oncohematology. Naukova Dumka, Kiev, pp.64-104, 1990.(Russian)
2. Clark, E.A., I. Berberich, S.J. Klaus, C.-L. Law, and S.P. Sidorenko. Accessory molecules which influence signaling through B lymphocyte antigen receptors. In: Mechanisms of Lymphocyte Activation and Immune Regulation V. (ed. S. Gupta, A. Defranco, W. Paul, and R. Perlmutter), Plenum Press. Adv. Exp. Med. Biol. 365: 35-43, 1994.
3. Law, C.-L., S.P. Sidorenko, and E.A. Clark. Regulation of lymphocyte activation by the cell surface molecule CD22. Immunology Today 15:442-449, 1994.
4. Sidorenko, S.P., and E.A. Clark. Activation panel mAb IPO-3 recognizes a novel activation marker of T and B lymphocytes. In: Leucocyte Typing V (ed. S. Schlossman et al.), Oxford University Press, I:1160-1662, 1995.
5. Sidorenko, S.P., K.A. Chandran, and E.A. Clark. Identification of antigens associated with protein kinases by Activation panel mAb. In: Leucocyte Typing V (ed. S. Schlossman et al.), Oxford University Press, I:1175-1177, 1995.
6. Law, C.-L., A. Craxton, K.L. Otipoby, S.P. Sidorenko, S.J. Klaus, and E.A. Clark. Regulation of signaling through B lymphocyte antigen receptors by cell-cell interaction molecules. Immunolological Reviews., 153: 123-154, 1996.
7. Sidorenko, S.P., G. Shu, K.E. Draves, L.M. Pinchuk, S.V. Mikhalap, Z. Zhao, and E.A. Clark. The IPO-3/SLAM surface molecule associates with protein kinase activities and CD45 in B lymphocytes. In: Leucocyte Typing VI (ed. T. Kishimoto et al.), Garland Publishing, Inc., pp. 584-585, 1997.
8. Mikhalap, S.V., L.N. Shlapatskaya, O.V. Yurchenko, A.G. Berdova, D.F. Gluzman, and S.P. Sidorenko. Monoclonal antibody IPO-38 recognizes a novel nuclear antigen of proliferating cells. In: Leucocyte Typing VI (ed. T. Kishimoto et al.), Garland Publishing, Inc., pp.609-610, 1997.
9. Sidorenko, S.P. CDw150 cluster report. In: Leucocyte Typing VI (ed. T. Kishimoto et al.), Garland Publishing, Inc., pp. 582-584, 1997.
10. Sidorenko, S.P. Human cell surface antigens clustered at International Workshops on human leukocyte differentiation antigens. Immunol. Allergol. 3:16-38, 1998.
11. Mikhalap S.V., L.M.Shlapatska, G.G.Berdova, T.J.Yun, K.E.Nichols, E.A.Clark, S.P Sidorenko. CDw150 association with SHIP versus SHP-2 in B cells. Leucocyte Typing VII, Oxford University Press, pp.109-111, 2002.
12. Shlapatskaya, L.M., G.G.Berdova, S.V. Mikhalap, T.J.Yun, K.E..Nichols, E.A.Clark., S.P.Sidorenko. CDw150 modulates CD95-mediated apoptosis. Leucocyte Typing VII, Oxford University Press, pp.60-63, 2002.
13. Sidorenko, S.P. CD150 cluster report. Leucocyte Typing VII, Oxford University Press, pp.104-106, 2002.
14. Yurchenko, O.V., G.G.Berdova, L.M.Shlapatska, T.A. Tarasova, and S.P.Sidorenko. Expression of CD150 antigen in normal and tumour tissues. Leucocyte Typing VII, Oxford University Press, pp.107-108, 2002.
15. Shishova, Yu.V., O.V. Yurchenko, M.A. Vodyanik, S.P.Sidorenko, and V.F. Chekhun. Enhanced CD95-mediated apoptosis in the cisplatin-resistant cell line KB/DDP5. Leucocyte Typing VII, Oxford University Press, pp.58-60, 2002.
16. Sidorenko, S.P. and E.A. Clark. The dual-function CD150 receptor subfamily: the viral attraction. Nat. Immunol., 4:19-24, 2003.
17. Sidorenko S.P., Mikhalap S.V., Shlapatska L.M., Yurchenko M.Y., Akimov Y.M.,Chekhun V.F. Signal transduction pathways initiated via cell surface receptor CD150: in silico and in vitro analysis. In: Bioinformatics of Genome Regulation and structure (ed. Kolchanov and Hofestaedt), Kluver Academic Publishers, Boston/Dortrecht/London. 203-210, 2004.